Drug Therapy

Treatment provided on a clinical trial protocol

Check the appropriate box whether the patient participated on a clinical trial during initial course of chemotherapy.

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Chemotherapy administered during initial treatment course?

Check if the patient received chemotherapy administered during their initial treatment course.

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Was neoadjuvant chemotherapy administered?

For GYN cases only. Indicate if the patient received neoadjuvant chemotherapy. If the patient received chemotherapy but did not have surgery, answer “yes” to this question.

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For gynecologic oncology cases in which the patient receives chemotherapy but there is no surgery performed, abstractors will need to choose BOTH “chemotherapy administered” and “neoadjuvant chemotherapy administered” in order for the chemotherapy drug information to populate. This will also populate the additional “was patient given anticoagulation medications concurrently with neoadjuvant chemotherapy” as well as the pre chemotherapy lab results data items.

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Route of Neoadjuvant chemotherapy

Check the box in which the route of neoadjuvant chemotherapy was given. Check all that apply.

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Was the patient given anticoagulation medications concurrently with neoadjuvant chemotherapy?

For GYN cases only. Indicate if the patient was prescribed any of the anticoagulation medications listed in the help text within 30 days of starting neoadjuvant chemotherapy. Anticoagulation medications include LMWH/low molecular weight heparin,Warfarin/Coumadin, Apixaban/Eliquis, Rivaroxaban/Xarelto, Fondaparinux/Arixtra,Dabigatran/Pradaxa, and Edoxaban/Savaysa. “Concurrently” is defined as +/-30 days from neoadjuvant therapy start date

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  • If a patient is already on long-term anticoagulation for another reason prior to the start of neoadjuvant chemotherapy, indicate yes for anticoagulation prescribed with neoadjuvant chemotherapy and indicate the date the patient was started on anticoagulation therapy.
  • If you can only locate the month and year the patient began anticoagulation therapy, indicate the first day of the month and year known.  For example, if the patient was prescribed Apixaban on 5/2016, enter 05/01/2016
  • If you can not locate any information about the date the patient was prescribed anticoagulation therapy, enter the same date as the date of the start of neoadjuvant chemotherapy.
  • If you are unable to find the term “contraindicated” documented in the provider notes, mark “no”
  • If you are unable to find the reason VTE Prophylaxis is contraindicated, leave the (specify Reason, if given) free text field blank.
  • Do not spend more than 5 minutes searching for the reason for contraindication

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Anticoagulation Medication Type

If you answer "Yes" to the patient given anticoagulation medications concurrently with neoadjuvant chemotherapy, then indicate what anticoagulation medications were given to the patient within 30 days of starting.

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Was adjuvant chemotherapy administered?

For GYN cases only. Indicate if the patient received adjuvant chemotherapy after their surgery. If the patient did not have surgery, answer “No” to this question.

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Route of Adjuvant Chemotherapy

Check the box in which the route of adjuvant chemotherapy was given. Check all that apply.

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Neoadjuvant chemotherapy start date

If you answered yes to patient received neoadjuvant, enter the start date for any/all neoadjuvant chemotherapy routes selected.

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Adjuvant chemotherapy start date

If you answered yes to patient received adjuvant, enter the start date for any/all adjuvant chemotherapy routes selected.

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Start Date IV chemotherapy during Cycle 1 of Initial Anticancer therapy Treatment

Provide the start date for the IV chemotherapy during Cycle 1 of initial anticancer therapy treatment. If patient received both neoadjuvant & adjuvant chemotherapy, use start date of neoadjuvant chemotherapy.

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Did the regimen contain Cisplatin?

Indicate whether or not the patient received Cisplatin at any point during the initial regimen, not just Cycle 1.

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Did the regimen contain Carboplatin?

Indicate whether or not the patient received Carboplatin at any point during the initial regimen, not just Cycle 1.

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What is the AUC?

If the patient received Carboplatin, enter the Carboplatin AUC.

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Did the regimen contain Taxane?

Indicate whether or not the patient received Taxane at any point during the initial regimen, not just Cycle 1.

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Taxanes

  • Generic = paclitaxel, docetaxel
  • Brand = Taxol, Abraxane, Taxotere

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Did the regimen contain Doxorubicin & Cyclophosphamide?

Indicate whether or not the patient received Doxorubicin & Cyclophosphamide at any point during the initial regimen, not just Cycle 1.

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Did the patient receive FOLFIRINOX (irinotecan, oxaliplatin, 5-FU, and leucovorin)?

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Emetic Risk for Chemotherapy received

Indicate the emetic risk of the patients chemotherapy regimen given for Cycle 1, day 1 of initial IV chemotherapy. Review the chemotherapy flowsheet. Respond based on the highest Emetic risk agent administered, if more than one chemotherapy drug administered.

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Refer to MOQC’s Emetic Risk vs immunotherapy drug list. MOQCs Emetic Risk vs Immunotherapy Document

NOTE: This document is updated periodically.

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Is this patient participating in an antiemetic clinical trial?

Indicate if the patient is on an antiemetic clinical trial.

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NK1 Receptor Antagonist Administered

If more than one high emetic risk drug was administered, reference the first administration when checking for aprepitant (Emend) OR netupitant (AKYNZEO®) or rolapitant.

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Start Date NK1 Receptor Antagonist Administered

Provide start date for the NK1 Antagonist Administered for Cycle 1 IV Chemotherapy.

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Was Olanzapine prescribed

During Cycle 1 of initial IV chemotherapy, indicate if olanzapine was prescribed.

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Common brand names for olanzapine: Zyprexa Relprevv, Zyprexa Zydis, Zyprexa

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Documented intent of chemotherapy within 60 days prior or 14 days after anticancer therapy administration

This question will only populate for ovarian, fallopian tube, and primary peritoneal cancers and no longer populates for medical oncology. Indicate whether there is documentation/acknowledgement of intent for the initial treatment course, by a practitioner in the practice. • Palliation may be to prolong life (without goal of cure) or to control symptoms.

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PARP-Inhibitor prescribed (GYN ONC Cohort only)

Documentation may be found under the oncology treatment or medication section in the EMR, as they are usually given as tablets or capsules. Enter whether the PARP-Inhibitor was prescribed (yes or no), which one was prescribed (from the 3 choices) and the date that the PARP-Inhibitor was prescribed. If the prescribed date cannot be determined, choose the unknown box for the date.

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PARP-Inhibitor type (GYN ONC Cohort only)

Choose between Olaparib, Rucaparib, Niraparib or unknown.

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Date PARP-Inhibitor prescribed (GYN ONC Cohort Only)

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